Publications

Integrated Muscle Protein Synthesis During Disuse and Rehabilitation in Late-Midlife Adults
Sean P Kilroe, Zachary D Von Ruff, Hanna Kalenta, Vladislav Bugay, Emily J. Arentson-Lantz, Andrew J. Murton, Victoria G. Rontoyanni, Doaa R. Abdelrahman, Elena Volpi, Doug Paddon-Jones, and Blake B. Rasmussen
American Journal of Physiology. 2025 September 4. doi.org/10.1152/ajpregu.00072.2025

Patient and Caregiver Outcomes of Health System, Community-Based, and Usual Dementia Care:
A Prespecified Analysis of the Dementia Care Study (D-CARE) Randomized Clinical Trial
David B. Reuben, Alan B. Stevens, Thomas M. Gill, Jeff Williamson, Elena Volpi, Maya L. Lichtenstein, Lee A. Jennings, Rebecca Galloway, Jenny Summapund, Katy Araujo, David Bass, Lisa Weitzman, Zaldy S. Tan, Leslie C. Evertson, Mia Yang, Aval-Na’Ree S. Green, Rafael Samper-Ternent, Pamela Borek, Yunshan Xu, Peter Peduzzi, and Erich J. Greene.
JAMA Intern Med. 2025 September 2. doi: 10.1001/jamainternmed.2025.4247

Endurance training enhances sex-specific cardioprotective metabolism
Pauline Brochet, Samuel Montalvo, Malene E Lindholm, David Jimenez-Morales, Christopher A Jin, Blake B Rasmussen, William E Kraus, Zhen Yan, Matthew T Wheeler, Daniel Katz
Circulation Research. 2025 Aug 27. doi.org/10.1161/circresaha.125.326494

Sex as a major determinant of pro-longevity drug efficacy: a review of two decades of the NIA Interventions Testing Program
Nisi Jiang, PhD , Ziying Xu, MS , Shangang Zhao, PhD , Jonathan Gelfond, MD, PhD , Randy Strong, PhD , James F Nelson, PhD, FGSA
The Journals of Gerontology: Series A. 2025 Aug. doi.org/10.1093/gerona/glaf138

End-of-life pathology in UM-HET3 mice treated with 16 α‑hydroxyestradiol or late‑start canagliflozin
Jessica M. Snyder, David E. Harrison, Ron Korstanje, Brett Ginsburg, Peter C. Reifsnyder, James Nelson, Scott Leiser, Catherine Kaczorowski, Denise M. Imai, Adam B. Salmon, Randy Strong, Warren Ladiges, Richard A. Miller
GeroScience. 2025 July 2. doi.org/10.1007/s11357-025-01741-3

Low-Frequency Ultrasound Reverses Insulin Resistance and Diabetes Induced Changes in the Muscle Transcriptome in Aged Mice
Erik D Marchant, Ekta Singh, Sanjay Kureel, Brandon Blair, Hanna Kalenta, Zachary D Von Ruff, Korri S Weldon, Zhao Lai, Michael P Sheetz, Blake B Rasmussen
Am J Physiol Endocrinol Metab. 2025 May 5. doi: 10.1152/ajpendo.00470.2024.

Human skeletal muscle disuse atrophy has profound and negative effects on the muscle metabolome and lipidome
Sean P Kilroe, Zachary Von Ruff, Emily J Arentson-Lantz, Trevor B Romsdahl, Jennifer J Linares, Hanna Kalenta, Erik D Marchant, Elena Volpi, Douglas Paddon-Jones, William K Russell, Blake B Rasmussen
Am J Physiol Endocrinol Metab. 2025 Apr 29. doi.10.1152/ajpendo.00012.2025

Metabolic dysregulation and resistance to high-fat diet-induced weight gain in mice overexpressing human wild-type α-synuclein
K. C. Biju, Enrique Torres Hernandez, Alison Michelle Stallings, Ada C. Felix-Ortiz, Skanda K. Hebbale, Luke Norton, Michael J. Mader, Robert A. Clark
npj Parkinsons Dis. 11, 90 (2025). doi.org/10.1038/s41531-025-00961-w

Evaluation of exploratory fluid biomarkers from a phase 1 senolytic trial in mild Alzheimer’s disease
Valentina R. Garbarino, Juan Pablo Palavicini, Justin Melendez, Nicolas R. Barthelemy, Yingxin He, Tiffany F. Kautz, Marisa Lopez-Cruzan, Julia J. Mathews, Peng Xu, Bin Zhang, Afaf Saliba, Nagarjunachary Ragi, Kumar Sharma, Dallin Mason, Samuel Johnson, Suzanne Hendrix, Suzanne Craft, Ronald C. Petersen, Jair Machado Espindola-Netto, Ailing Xue, Miranda E. Orr
Neurotherapeutics. 2025 Apr 23. doi.org/10.1016/j.neurot.2025.e00591

Constitutively Active mTORC1 Signaling Modifies the Skeletal Muscle Metabolome and Lipidome Response to Exercise
Hanna Kalenta, Sean P Kilroe, Trevor B Romsdahl, Erik D Marchant, Rosario Maroto, Jennifer J Linares, William K Russell, Blake B Rasmussen
J Appl Physiol. 2025 Apr 11. doi: 10.1152/japplphysiol.00987.2024

The Spatial Transcriptional Activity of Hepatic TCF7L2 Regulates Zonated Metabolic Pathways that Contribute to Liver Fibrosis
Iriscilla Ayala, Skanda K. Hebbale, Juho Mononen, Madelaine C. Brearley-Sholto, Christopher E. Shannon, Ivan Valdez, Marcel Fourcaudot, Terry M. Bakewell, Anna Zagorska, Giovanna Romero, Mara Asmis, Fatima A. Musa, Jonah T. Sily, Annie A. Smelter, Edgar A. Hinostroza, Leandro C. Freitas Lima, Thomas Q. de Aguiar Vallim, Sami Heikkinen, Luke Norton
Nature Communications. 2025 Apr 10. doi.org/10.1038/s41467-025-58714-5

The impact of lifestyle-based weight loss in older adults with obesity on muscle and bone health: a balancing act
Tiffany M. Cortes, Kacey Chae, Colleen M. Foy, Denise K. Houston, Kristen M. Beavers
Obesity. 2025 Mar 10. doi.org/10.1002/oby.24229

Mitochondrial ACSS1-K635 acetyliation knock-in mice exhibit altered liver lipid metabolism on a ketogenic diet
Guogang Xu, Joseph R. Schell, Songhua Quan, Yucheng Goo, Sung-Jei Wei, Meixia Pan, Xianlin Han, Doahong Zhou, Haiyan Jiang, Felix F. Dong, Erin Munkascy, Nobuo Horikoshi, David Gius
Free Radical Biology and Medicine. 2025 Mar 10. doi.org/10.1016/j.freeradbiomed.2025.03.009

Rejuvenation of senescent cells, in vintro and in vivo, by low-frequency ultrasound
Sanjay K Kureel, Rosario Maroto, Maisha Aniqua, Simon Powell, Ekta Singh, Felix Margadant, Brandon Blair, Blake B Rasmussen, Michael P Sheetz
Aging Cell. 2025 Mar 3:e70008. doi:10.1111/acel.70008. Online ahead of print.

Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle
Zachary D Von Ruff, Matthew J Miller, Tatiana Moro, Paul T Reidy, Scott M Ebert, Elena Volpi, Christopher M Adams, Blake B Rasmussen
Geroscience. 2025 Feb 27. doi:  0.1007/s11357-025-01564-2

Microglial cGAS Deletion Preserves Intercellular Communication and Alleviates Amyloid-β-Induced Pathogenesis of Alzheimer’s Disease
Sijia He, Xin Li, Namrata Mittra, Anindita Bhattacharjee, Hu Wang, Shujie Song, Shangang Zhao, Feng Liu, Xianlin Han
Adv Sci (Weinh). 2025 Feb 5:e2410910. doi: 10.1002/advs.202410910

Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications
Sinja He, Ziying Xu, Xianlin Han
Mol Neurodegeneration. 2025 20(10): doi.org/10.1186/s13024-025-00803-6

The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury
Hak Joo Lee, Yuyang Sun, Falguni Das, Wenjun Ju, Viji Nair, Christopher G. Kevil, Shankara Varadarajan, Guanshi Zhang, Goutam Ghosh Choudhury, Brij B. Singh, Matthias Kretzler, Robert G. Nelson, Kumar Sharma, Balakuntalam S. Kasinath
JC Insight. 2025; 10(10): e174848. doi.org/10.1172/jci.insight.174848

High glucose couples DJ-1 with PTEN to activate PDGFRβ for renal proximal tubular cell injury
Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S. Kasinath, Kumar Sharma, Goutam Ghosh Choudhury
PLoS ONE. 6 Jan 2025: 20(1): e0311828. https://doi.org/10.1371/journal.pone.0311828

Effect of semaglutide on physical function, body composition, and biomarkers of aging in older adults
Tiffany Cortes, Ronna Robbins, Monica Serra, Sara Espinoza, Nicolas Musi, Hannah Barrus, Kevin Brown, Annalis Campos
Innov Aging. 2024 Dec 31;8(Suppl 1):322–323. doi: 10.1093/geroni/igae098.1054.

GLP1Ra-based therapies and DXA-acquired musculoskeletal health outcomes: a focused meta-analysis of placebo-controlled trials
Kristen M Beavers, Tiffany M Cortes, Colleen M Foy, Lauren Dinkla, Fernando Reyes San Martin, Jamy D Ard, Monica C Serra, Daniel P Beavers
Obesity. 2024 Dec 22: doi: 10.1002/oby.24172.

Myelin Lipid Alterations in Neurodegenerative Diseases: Landscape and Pathogenic Implications
Ziying Xu, Sijia He, Mst Marium Begun, Xianlin Han
Antioxidants & Redox Signaling. 2024 Nov 22: doi.org/10.1089/ars.2024.0676

Diet-enhanced LRG1 expression promotes insulin hypersecretion and ER stress in pancreatic beta cells
Desirae D. Morales, Jiyoon Ryu, Cong Wei, Jason T. Hadley, Maia R. Smith, Julie Bai, Juan C. Lopez-Alvarenga, Srinivas Mummidi, Ravindranath Duggirala, Jane L. Lynch, Feng Liu, Lily Q. Dong
Diabetologia. 2024 Nov 26: doi.org/10.1007/s00125-024-06331-0

Robust assembly of electron transfer chain in the brain of naked mole-rat during aging
Ting Liang, Belinda Bernal, Wenbo Qi, Yuji Ikeno, Adam Salmon, Daisy Kwok, Joel Michalek, Mai Zhou, Yidong Bai
Organelle. 2024 Nov 8: doi.org/10.61747/0ifp.202408002

HADHA regulates respiratory complex assembly and couples FAO and OXPHOS
Chaoying Qin, Sasha Gong, Ting Liang, Zhenbo Zhang, Jessie Thomas, Janice Deng, Yaguang Liu, Peiqing Hu, Bi Zhu, Shujie Song, Marisol Fernandez Ortiz, Yuji Ikeno, Exing Wang, James Lechleiter, Susan T. Weintraub, Yidong Bai
Adv. Sci. 2024 Nov 3: doi.org/10.1002/advs.202405147

The mitochondrial pyruvate carrier regulates adipose glucose partitioning in female mice
Christopher E Shannon, Terry Bakewell, Marcel J Fourcaudot, Iriscilla Ayala, Annie A Smelter, Edgar A Hinostroza, Giovanna Romero, Mara Asmis, Leandro C Freitas LIma, Martina Wallace, Luke Norton
Mol. Met. 2024 Oct: doi.org/10.1016/j.molmet.2024.102005

Mouse models used to test the role of reactive oxygen species in aging and age-related chronic diseases
Hoang Van M. Nguyen, Qitao Ran, Adam B. Salmon, Bumsoo Ahn, Ying Ann Chiao, Shylesh Bhaskaran, Arlan Richardson
Free Radical Biology & Medicine. 2024 Oct 16: doi.org/10.1016/j.freeradbiomed.2024.10.269

Analysis of early effects of human APOE isoforms on Alzheimer’s disease and type III hyperlipoproteinemia pathways using knock-in rat models with humanized APP and APOE
Metin Yesiltepe, Tao Yin, Marc Tambini, Hanmei Bao, Meixia Pan, Cristina d’Abramo, Luca Giliberto, Xianlin Han, D’Adamio Luciano
Cell Commun Signal.  2024 Sept 27: 22(1):458. doi.org/10.1186/s12964-024-01832-2

Technical development of Senescence-Associated β-Galactosidase staining in frozen kidney tissue of Sprague Dawley rat
Tandukar, G., Flores, L.C., Allen, C., Bai, Y., and Ikeno, Y.  T.
Aging Pathobiol. Ther. 6: 117-124. DOI: 10.31491/APT.2024.09.150. 2024.

Effect of Semaglutide on Physical Function, Body Composition, and Biomarkers of Aging in Older Adults With Overweight and Insulin Resistance: Protocol for an Open-Labeled Randomized Controlled Trial
Tiffany M Cortes, Libia Vasquez, Monica C Serra, Ronna Robbins, Allison Stepanenko, Kevin Brown, Hannah Barrus, Annalisa Campos, Sara E Espinoza, Nicolas Musi
JMIR Res Protoc. 2024 Sept 13:e62667. doi:10.2196/62667

A pilot study evaluating dosing tolerability of 17a-estradiol in male common marmosets (Callithrix jacchus)
Roshini Sathiaseelan, Jose V.V. Isola, Roberto Santin-Marquiz, Daniel Adekunbi, Michal Fornalik, Adam B. Salmon, Michael B. Stout
Geroscience. 2024 Aug 6: doi.org/10.1007/s11357-024-01311-z

Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function
Binsheng Wang, Lichao Wang, Nathan S. Gasek, Chia-Ling Kuo, Jia Nie, Taewan Kim, Pengyi Yan, Junyu Zhu, Blake L. Torrance, Yueying Zhou, Lisa C. Flores, Colton Allen, Allison M. Andrade, Chun Guo, Rachel L. Cohn, Evan R. Jellison, Jenna M. Bartley, George A. Kuchel, Sheng Li, Tamar Pirtskhalava, Tamar Tchkonia, Sumit Yadav, Laura Haynes, James L. Kirkland, Yuji Ikeno, Ming Xu
Cell Metab. 2024 Aug 6: doi.org/10.1016/j.cmet.2024.07.006

Targeting S6K/NFκB/SQSTM1/Polθ signaling to suppress radiation resistance in Prostate Cancer
Alison Clark, Michelle R. Villarreal, Shih-Bo Huang, Sridharan Jayamohan, Paul Rivas, Suleman S. Hussain, Meagan Ybarra, Pawel Osmulski, Maria E. Gaczynska, Eun Yong Shim, Tyler Smith, Yogesh K. Gupta, Xiaoyu Yang, Caroline R. Delma, Mohan Natarajan, Zhao Lai, Li-Ju Wang, Joel E. Michalek, Daniel S. Higginson, Yuji Ikeno, Addanki P. Kumar
Cancer Letters. 2024 June 24: doi.org/10.1016/j.canlet.2024.217063

278-OR: Single-nucleus multiomics profiling across 49 individuals of Hispanic ancestry reveals cell-specific muscle insulin-responsive gene regulatory signatures
Benjamin Li, Arushi Varshney, Adelaide Tover, Nandini Manickam, Peter Orchard, Ralph A. DeFronzo, Luke Norton, Stephen Parker
Diabetes. 2024 June 14: doi.org/10.2337/db24-278-OR

High glucose-induced downregulation of PTEN-Long is sufficient for proximal tubular cell injury in diabetic kidney disease
Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S. Kasinath, Kumar Sharma, Goutam Ghosh Choudhury
Experimental Cell Research. 2024 June 1: doi.org/10.1016/j.yexcr.2024.114116

Does rapamycin treatment alter age-associated changes in liver proteome profile of a unique non-human primate model?
Amrita Kamat, Parveez A Abdul Azees, Hanzhou Wang, Juan Pablo Palavicini, Xianlin Han, Susan E. Weintraub, Adam Salmon
Physiology. 2024 May 21. doi.org/10.1152/physiol.2024.39.S1.2541

Ketogenic diet induces p53-dependent cellular senescence in multiple organs
Sung-Jen Wei, Joseph Schell, E. Sandra Chocron, Mahboubeh Varmazyad, Guogang Xu, Wan Hsi Chen, Gloria M. Martinez, Felix F. Dong, Prethish Sreenivas, Rolando Trevino Jr., Haiyan Jiang, Yan Du, Afaf Saliba, Wei Quian, Brandon Lorenzana, Alia Nazarullah, Jenny Chang, Kumar Sharma, Erin Munkascy, Nobuo Horikoshi, David Guis
Cell Biology. 2024 May 17: 10(20):1463. doi: 10.1126/sciadv.ado1463

Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease
Guogang Xu, Songhua Quan, Joseph Schell, Yucheng Gao, Mahboubeh Varmazyad, Prethish Sreenivas, Diego Cruz, Haiyan Jiang, Meixia Pan, Xianlin  Han, Juan Pablo Palavicini, Peng Zhao, Xiaoli Sun, Erik D. Marchant, Blake B. Rasmussen, Guannan Li, Sakie Katsumura, Masahiro Morita, Erin Munkacsy, Nobuo Horikoshi, E. Sandra Chocron, David Guis
Science Advances. 2024 May 17; 10(20):5942. doi: 10.1126/sciadv.adj5942

Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin
Richard A. Miller, David E. Harrison, Gino A. Cortopassi, Ishmael Dehghan, Elizabeth Fernandez, Michael Garratt, John G. Geisler, Brett C. Ginsburg, Melissa L. Han, Catherine C. Kaczorowski, Navasuja Kumar, Scott F. Leiser, Marisa Lopez-Cruzan, Ginger Milne, James R. Mitchell, James F. Nelson, Peter C. Reifsnyder, Adam B. Salmon, Ron Korstanje, Nadia Rosenthal, Randy Strong
Geroscience. 2024 May 16; https://doi.org/10.1007/s11357-024-01176-2

Brain-muscle communication prevents muscle aging by maintaining daily physiology
Arun Kumar, Mireia Vaca-Dempere, Thomas Mortimer, Oleg Deryagin, Jacob G Smith, Paul Petrus, Kevin B Koronowski, Carolina M Greco, Jessica Segalés, Eva Andrés, Vera Lukesova, Valentina M Zinna, Patrick-Simon Welz, Antonio L Serrano, Eusebio Perdiguero, Paolo Sassone-Corsi, Salvador Aznar Benitah, Pura Muñoz-Cánoves
Science. 2024 May 3;384(6695):563-572. doi: 10.1126/science.adj8533.

Enhancing Flow Mediated Dilation Analysis by Optimizing an Open-Source Software with Automated Edge Detection
Kseniya S. Masterova, Jiefei Wang, Courtney Mack, Tatiana Moro, Rachel Deer, Elena Volpi
J Appl Physiol. 2024 May 2.doi: 10.1152 /japplphysiol.00063.2023. Online ahead of print.

The mitochondrial multi-omic response to exercise training across rat tissues
David Amar, Nicole R Gay, David Jimenez-Morales, Pierre M Jean Beltran, Megan E Ramaker, Archana Natarajan Raja, Bingqing Zhao, Yifei Sun, Shruti Marwaha, David A Gaul, Steven G Hershman, Alexis Ferrasse, Ashley Xia, Ian Lanza, Facundo M Fernández, Stephen B Montgomery, Andrea L Hevener, Euan A Ashley, Martin J Walsh, Lauren M Sparks, Charles F Burant, R Scott Rector, John Thyfault, Matthew T Wheeler, Bret H Goodpaster, Paul M Coen, Simon Schenk, Sue C Bodine, Malene E Lindholm; MoTrPAC Study Group
Cell Metab. 2024 Apr 15:S1550-4131(23)00472-2. doi: 10.1016/j.cmet.2023.12.021. Online ahead of print. Epub 2024 May 2.

Temporal dynamics of the multi-omic response to endurance exercise training
MoTrPAC Study Group
Nature. 2024 May; 629(8010):174-183. doi: 10.1038/s41586-023-06877-w. Epub 2024 May 1.

Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue
Gina M Many, James A Sanford, Tyler J Sagendorf, Zhenxin Hou, Pasquale Nigro, Katie L Whytock, David Amar, Tiziana Caputo, Nicole R Gay, David A Gaul, Michael F Hirshman, David Jimenez-Morales, Malene E Lindholm, Michael J Muehlbauer, Maria Vamvini, Bryan C Bergman, Facundo M Fernández, Laurie J Goodyear, Andrea L Hevener, Eric A Ortlund, Lauren M Sparks, Ashley Xia, Joshua N Adkins, Sue C Bodine, Christopher B Newgard, Simon Schenk; MoTrPAC Study Group
Nat Metab. 2024 May 1. doi: 10.1038/s42255-023-00959-9. Online ahead of print.

The impact of exercise on gene regulation in association with complex trait genetics
Nikolai G Vetr, Nicole R Gay; MoTrPAC Study Group; Stephen B Montgomery.
Nat Commun. 2024 May 1;15(1):3346. doi: 10.1038/s41467-024-45966-w.

The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis
Thomas Mortimer, Valentina M. Zinna, Muge Atalay, Carmelo Laudanna, Oleg Deryagin, Guillem Posas, Jacob G. Smith, Elisa García-Lara, Mireia Vaca-Dempere, Leonardo Vinícius Monteiro de Assis, Isabel Heyde, Kevin B. Koronowski, Paul Petrus, Carolina M. Greco, Stephen Forrow, Henrik Oster, Paolo Sassone-Corsi, Patrick-Simon Welz, Pura Muñoz-Cánoves, Salvador Aznar Benitah
Cell Stem Cell. 2024 May; doi.org/10.1016/j.stem.2024.04.013

Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures
Venugopalan D Nair, Hanna Pincas, Gregory R Smith, Elena Zaslavsky, Yongchao Ge, Mary Anne S Amper, Mital Vasoya, Maria Chikina, Yifei Sun, Archana Natarajan Raja, Weiguang Mao, Nicole R Gay, Karyn A Esser, Kevin S Smith, Bingqing Zhao, Laurens Wiel, Aditya Singh, Malene E Lindholm, David Amar, Stephen Montgomery, Michael P Snyder, Martin J Walsh, Stuart C Sealfon; MoTrPAC Study Group
Cell Genom. 2024 Apr 29:100421. doi: 10.1016/j.xgen.2023.100421. Online ahead of print.

Female protection against diabetic kidney disease is regulated by kidney-specific AMPK activity
Hak Joo Lee, Liang Min, Jingli Gao, Shane Matta, Viktor Drel, Afaf Saliba, Ian Tamayo, Richard Montellano, Leila Hejazi, Soumya Maity, Guogang Xu, Brian I Grajeda, Sourav Roy, Kenneth R Hallows, Goutam Ghosh Choudhury, Balakuntalam S Kasinath, Kumar Sharma
Diabetes. 2024 Apr 24:db230807. doi: 10.2337/db23-0807. Online ahead of print.

SLGT2 inhibitors: cardiorenal metabolic drugs for the ages
Ralph DeFronzo
J Clin Invest. 2024 Mar 1;134(5):e177625. doi: 10.1172/JCI177625.

Effect of Dapagliflozin on Renal and Hepatic Glucose Kinetics in T2DM and NGT Subjects
Xi Chen, Devjit Tripathy, Robert Chilton, Andrea Hansis-Diarte, Marzieh Salehi, Carolina Solis-Herrera, Eugenio Cersosimo, Ralph A DeFronzo
Diabetes. 2024 Mar 21:db230457. doi: 10.2337/db23-0457. Online ahead of print.

ERMA (TMEM94) is P-type ATPase transporter for Mg2+  update in endoplasmic reticulum
Neelanjan Vishnu, Manigandan Venkatesan, Travis R Madaris, Mridula K Venkateswaran, Kristen Stanley, Karthik Ramachandran, Adhishree Chidambaram, Abitha K Madesh, Wenli Yang, Jyotsna Nair, Melanie Narkunan, Tharani Muthukumar, Varsha Karanam, Leroy C Joseph, Amy Le, Ayodeji Osidele, M Imran Aslam, John P Morrow, May C Malicdan, Peter B Stathopulos, Muniswamy Madesh
Mol Cell. 2024 Mar 13:S1097-2765(24)00177-1. doi: 10.1016/j.molcel.2024.02.033. Online ahead of print.

Ursolic Acid Induces Beneficial Changes in Skeletal Muscle mRNA Expression and Increases Exercise Participation and Performance in Dogs with Age-Related Muscle Atrophy
Scott M Ebert, Celine S Nicolas, Paul Schreiber, Jaime G Lopez, Alan T Taylor, Andrew R Judge, Sarah M Judge, Blake B Rasmussen, John J Talley, Christophe A Rème, Christopher M Adams
Animals (Basel). 2024 Jan 5;14(2):186. doi: 10.3390/ani14020186.

Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients
Kumar Sharma, Guanshi Zhang, Jens Hansen, Petter Bjornstad, Hak Joo Lee, Rajasree Menon, Leila Hejazi, Jian-Jun Liu, Anthony Franzone, Helen C Looker, Byeong Yeob Choi, Roman Fernandez, Manjeri A Venkatachalam, Luxcia Kugathasan, Vikas S Sridhar, Loki Natarajan, Jing Zhang, Varun S Sharma, Brian Kwan, Sushrut S Waikar, Jonathan Himmelfarb, Katherine R Tuttle, Bryan Kestenbaum, Tobias Fuhrer, Harold I Feldman, Ian H de Boer, Fabio C Tucci, John Sedor, Hiddo Lambers Heerspink, Jennifer Schaub, Edgar A Otto, Jeffrey B Hodgin, Matthias Kretzler, Christopher R Anderton, Theodore Alexandrov, David Cherney, Su Chi Lim, Robert G Nelson, Jonathan Gelfond, Ravi Iyengar; Kidney Precision Medicine Project
J Clin Invest. 2023 Oct 16;133(20):e170341. doi: 10.1172/JCI170341.

Intervention in older urban-dwelling veterans with dysmobility: protocol for a pilot feasibility clinical trail
Ronna N Robbins, Monica C Serra, Lisa S Kilpela, Elizabeth A Parker, Rozmin Jiwani, Odessa Addison.
JMIR Res Protoc. 2022;11(7):e39192. URL: https://www.researchprotocols.org/2022/7/e39192. DOI: 10.2196/39192

The Influence of Branched-Chain Amino Acid Supplementation on Fatigue and Tryptophan Metabolism after acute and chronic exercise in older adults: Protocol for a pilot randomized controlled trial
Ronna N Robbins, Tiffany Cortes, Jason C O’Connor, Rozmin Jiwani, Monica C Serra
JMIR Res Protoc. 2023 Nov 1:12:e52199. doi: 10.2196/52199.

Metabolomic and Lipidomic Signature of Skeletal Muscle with Constitutively Active mTORC1
Rosario Maroto, Ted G Graber, Trevor B Romsdahl, Andrzej Kudlicki, William K Russell, Blake B Rasmussen
J Nutr. 2023 Oct 26:S0022-3166(23)72670-9.  doi: 10.1016/j.tjnut.2023.10.016. Online ahead of print.

Skeletal Muscle Transcriptome Alterations Related to Declining Physical Function in Older Mice
Ted G Graber, Rosario Maroto, Jill K Thompson, Steven G Widen, Zhaohui Man, Megan L Pajski, Blake B Rasmussen.
J Ageing Longev. 2023 Jun;3(2):159-178. doi: 10.3390/jal3020013. Epub 2022 May 31.

GADD45A is a mediator of mitochondrial loss, atrophy, and weakness in skeletal muscle
George R Marcotte, Matthew J Miller, Hawley E Kunz, Zachary C Ryan, Matthew D Strub, Patrick M Vanderboom, Carrie J Heppelmann, Sarah Chau, Zachary D Von Ruff, Sean P Kilroe, Andrew T McKeen, Jason M Dierdorff, Jennifer I Stern, Karl A Nath, Chad E Grueter, Vitor A Lira, Andrew R Judge, Blake B Rasmussen, K Sreekumaran Nair, Ian R Lanza, Scott M Ebert, Christopher M Adams.
JCI Insight. 2023 Oct 10:e171772. doi: 10.1172/jci.insight.171772. Online ahead of print.

Emergence of a New Gluco-Regulatory Mechanism for Glycemic Control with Dapagliflozin/Exenatide Therapy in Type 2 Diabetes
Eugenio Cersosimo, Mariam Alatrach, Carolina Solis-Herrera, Baskoy Gozde, John Adams, Andrea Hansis-Diarte, Amalia Gastaldelli, Alberto Chavez, Curtis Triplitt, Ralph A DeFronzo.
J Clin Endocrinol Metab. 2023 Jul 22:dgad438. doi: 10.1210/clinem/dgad438. Online ahead of print.

Postabsorptive muscle protein synthesis is higher in outpatients as compared to inpatients
Paul T Reidy, Michael S Borack, Jared M Dickinson, Chad C Carroll, Nicholas A Burd, Micah J Drummond, Christopher S Fry, Bradley S Lambert, David M Gundermann, Erin L Glynn, Melissa M Markofski, Kyle L Timmerman, Tatiana Moro, Elena Volpi, Scott Trappe, Todd A Trappe, Matthew P Harber, Blake B Rasmussen.
Am J Physiol Endocrinol Metab. 2023 Aug 1;325(2):E113-E118. doi: 10.1152/ajpendo.00144.2023. Epub 2023 Jun 14.

Plasma insulin is required for the increase in plasma angiopoietin-link protein 8 in response to nutrient ingestion
Mohamed Abu-Farha, Mariam Alatrach, Jehad Abubaker, Irina Al-Khairi, Preethi Cherian, Krisitn Agyin, Siham Abdelgani, Luke Norton, John Adams, Dalal Al-Saeed, Ebaa Al-Ozairi, Ralph A. DeFronzo, Fahd Al-Mulla, Muhammad Abdul-Ghani
Diabetes Metab Res Rev. 2023: 39(6):e3643. doi.org/10.1002/dmrr.3643

Pioglitazone reduces epicardial fat and improves diastolic function in patients with type 2 diabetes
Alexander J Moody, Marjorie Molina-Wilkins, Geoffrey D Clarke, Aurora Merovci, Carolina Solis-Herrera, Eugenio Cersosimo, Robert J Chilton, Patricia Iozzo, Amalia Gastaldelli, Muhammad Abdul-Ghani, Ralph A DeFronzo.
Diabetes Obes Metab. 2023 Feb;25(2):426-434. doi: 10.1111/dom.14885. Epub 2022 Nov 4.

FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes
Ricardo J Samms, Christine C Cheng, Marcel Fourcaudot, Sami Heikkinen, Ahmed Khattab, John Adams, Eugenio Cersosimo, Curtis Triplitt, Curtis Puckett, Kostas Tsintzas, Andrew C Adams, Muhammad A Abdul-Ghani, Ralph A DeFronzo, Luke Norton.
Am J Physiol Endocrinol Metab.  2022 Aug 1;323(2):E123-E132. doi: 10.1152/ajpendo.00050.2022. Epub 2022 Jun 20.

Insulin: The master regulator of glucose Metabolism
Luke Norton, Chris Shannon, Amalia Gastaldelli, Ralph A DeFronzo.
Metabolism. 2022 Apr:129:155142. doi: 10.1016/j.metabol.2022.155142. Epub 2022 Jan 20.