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Effect of Semaglutide on Physical Function, Body Composition, and Biomarkers of Aging in Older Adults With Overweight and Insulin Resistance: Protocol for an Open-Labeled Randomized Controlled Trial
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A pilot study evaluating dosing tolerability of 17a-estradiol in male common marmosets (Callithrix jacchus)
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Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function
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Targeting S6K/NFκB/SQSTM1/Polθ signaling to suppress radiation resistance in Prostate Cancer
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High glucose-induced downregulation of PTEN-Long is sufficient for proximal tubular cell injury in diabetic kidney disease
Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S. Kasinath, Kumar Sharma, Goutam Ghosh Choudhury
Experimental Cell Research. 2024 June 1: doi.org/10.1016/j.yexcr.2024.114116
Does rapamycin treatment alter age-associated changes in liver proteome profile of a unique non-human primate model?
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Ketogenic diet induces p53-dependent cellular senescence in multiple organs
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Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease
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Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin
Richard A. Miller, David E. Harrison, Gino A. Cortopassi, Ishmael Dehghan, Elizabeth Fernandez, Michael Garratt, John G. Geisler, Brett C. Ginsburg, Melissa L. Han, Catherine C. Kaczorowski, Navasuja Kumar, Scott F. Leiser, Marisa Lopez-Cruzan, Ginger Milne, James R. Mitchell, James F. Nelson, Peter C. Reifsnyder, Adam B. Salmon, Ron Korstanje, Nadia Rosenthal, Randy Strong
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Brain-muscle communication prevents muscle aging by maintaining daily physiology
Arun Kumar, Mireia Vaca-Dempere, Thomas Mortimer, Oleg Deryagin, Jacob G Smith, Paul Petrus, Kevin B Koronowski, Carolina M Greco, Jessica Segalés, Eva Andrés, Vera Lukesova, Valentina M Zinna, Patrick-Simon Welz, Antonio L Serrano, Eusebio Perdiguero, Paolo Sassone-Corsi, Salvador Aznar Benitah, Pura Muñoz-Cánoves
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Enhancing Flow Mediated Dilation Analysis by Optimizing an Open-Source Software with Automated Edge Detection
Kseniya S. Masterova, Jiefei Wang, Courtney Mack, Tatiana Moro, Rachel Deer, Elena Volpi
J Appl Physiol. 2024 May 2.doi: 10.1152 /japplphysiol.00063.2023. Online ahead of print.
The mitochondrial multi-omic response to exercise training across rat tissues
David Amar, Nicole R Gay, David Jimenez-Morales, Pierre M Jean Beltran, Megan E Ramaker, Archana Natarajan Raja, Bingqing Zhao, Yifei Sun, Shruti Marwaha, David A Gaul, Steven G Hershman, Alexis Ferrasse, Ashley Xia, Ian Lanza, Facundo M Fernández, Stephen B Montgomery, Andrea L Hevener, Euan A Ashley, Martin J Walsh, Lauren M Sparks, Charles F Burant, R Scott Rector, John Thyfault, Matthew T Wheeler, Bret H Goodpaster, Paul M Coen, Simon Schenk, Sue C Bodine, Malene E Lindholm; MoTrPAC Study Group
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Temporal dynamics of the multi-omic response to endurance exercise training
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Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue
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The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis
Thomas Mortimer, Valentina M. Zinna, Muge Atalay, Carmelo Laudanna, Oleg Deryagin, Guillem Posas, Jacob G. Smith, Elisa García-Lara, Mireia Vaca-Dempere, Leonardo Vinícius Monteiro de Assis, Isabel Heyde, Kevin B. Koronowski, Paul Petrus, Carolina M. Greco, Stephen Forrow, Henrik Oster, Paolo Sassone-Corsi, Patrick-Simon Welz, Pura Muñoz-Cánoves, Salvador Aznar Benitah
Cell Stem Cell. 2024 May; doi.org/10.1016/j.stem.2024.04.013
Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures
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Female protection against diabetic kidney disease is regulated by kidney-specific AMPK activity
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SLGT2 inhibitors: cardiorenal metabolic drugs for the ages
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Effect of Dapagliflozin on Renal and Hepatic Glucose Kinetics in T2DM and NGT Subjects
Xi Chen, Devjit Tripathy, Robert Chilton, Andrea Hansis-Diarte, Marzieh Salehi, Carolina Solis-Herrera, Eugenio Cersosimo, Ralph A DeFronzo
Diabetes. 2024 Mar 21:db230457. doi: 10.2337/db23-0457. Online ahead of print.
ERMA (TMEM94) is P-type ATPase transporter for Mg2+ update in endoplasmic reticulum
Neelanjan Vishnu, Manigandan Venkatesan, Travis R Madaris, Mridula K Venkateswaran, Kristen Stanley, Karthik Ramachandran, Adhishree Chidambaram, Abitha K Madesh, Wenli Yang, Jyotsna Nair, Melanie Narkunan, Tharani Muthukumar, Varsha Karanam, Leroy C Joseph, Amy Le, Ayodeji Osidele, M Imran Aslam, John P Morrow, May C Malicdan, Peter B Stathopulos, Muniswamy Madesh
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Ursolic Acid Induces Beneficial Changes in Skeletal Muscle mRNA Expression and Increases Exercise Participation and Performance in Dogs with Age-Related Muscle Atrophy
Scott M Ebert, Celine S Nicolas, Paul Schreiber, Jaime G Lopez, Alan T Taylor, Andrew R Judge, Sarah M Judge, Blake B Rasmussen, John J Talley, Christophe A Rème, Christopher M Adams
Animals (Basel). 2024 Jan 5;14(2):186. doi: 10.3390/ani14020186.
